53Two is an events space and arts venue in a pair of railway arches on Watson St near the Beetham Tower. The bar sells keg beers from Brightside (all Vegan) and has recently added a cask beer. Pasties are available from HM Pasties Thursday to Sunday (or until they run out).

In December 2022 a handpull was installed for the Xmas trade and as this proved a success has remained.

This venue hosted the Central Manchester Beer and Cider festival in 2021 and 2022.